Hold your breath for this one! On our latest episode, The Curious Clinicians answer a puzzling pulmonary physiology question: Why can systemic pulmonary vasodilators worsen hypoxemia in COPD-associated pulmonary hypertension?

podcasts.apple.com/us/podcast/88-…

open.spotify.com/episode/0SJM2V…

1/14
What is the mechanism of night sweats?

We ask about 'fevers, chills, and NIGHT sweats', not 'fevers, chills, and DAY sweats.' Why?

To understand the answer, we'll need to cover temperature regulation, circadian rhythms, and more...

1/18
🤔Why does heart failure with preserved ejection fraction (HFpEF) lead to sodium retention?

With reduced ejection fraction (HFrEF), decreased cardiac output (CO) leads to neurohormonal activation and sodium avidity.

If CO is preserved in HFpEF, what's the inciting event?

1/
Why do patients with hyperbilirubinemia become jaundiced? Patients with hemochromatosis don’t get “scleral bronze”. Why does bilirubin “do' what it does?

The answers will require review of an article written 90 years ago, in German…

Don’t miss our first video podcast on YouTube!

Why do your fingers wrinkle in the bath?

youtu.be/V5cL_hd26JU?si…

Hannah, Avi, and I are very excited to announce our new Curious Clinicians YouTube page. Check out our first video and subscribe to see what we have in store!

youtube.com/channel/UCnhM2…

Things We Do for No Reason™: Routine respiratory pathogen panels for emergency department and hospitalized patients …mpublications.onlinelibrary.wiley.com/doi/full/10.10…

1/10
Does epinephrine improve outcomes in patients with cardiac arrest?

This is a question with a complex answer. This thread is only meant to scratch the surface and is a follow-up to a recent tweetorial on the use of epinephrine for cardiac arrest.

Tony Breu If you have an intervention that increases ROSC/survival but does not simultaneously protect the brain, then you will get more survivors with both good & bad neurological outcome with ratios likely dependent on median ROSC time. You would likely find the same for CPR/defib (1/n)

1/17
🤔Why do we use epinephrine to treat cardiac arrest?

Epinephrine can CAUSE cardiac arrest. And yet we give it as part of ACLS to treat the condition it caused.

This paradox requires explanation.

📣 Cool announcement! 📣

We have officially launched the The Curious Clinicians YouTube channel!

First episode answers the question, why do your fingers wrinkle in the bath?

youtu.be/V5cL_hd26JU?si…

1/
Why hasn’t group A strep (GAS) developed resistance to penicillin?

This is particularly odd given that other closely related gram-positive species (e.g., Strep pneumoniae) have resistant strains.

Given the global burden of disease, understanding GAS is essential...

Why do your fingers wrinkle when you take a bath?

Find out the answer on our latest episode, ‘Aquagenic Wrinkling’!

curiousclinicians.com/2024/04/17/epi…

podcasts.apple.com/us/podcast/the…

open.spotify.com/episode/5CwLIg…

1/16
🤔Why does subarachnoid hemorrhage lead to deep/inverted 'cerebral T-waves'?

This ECG finding is so dramatic. But as we will see, these patients often have normal hearts.

Why does an issue in the brain manifest on a test of the heart?

1/
How does acetaminophen decrease fever and pain, without affecting inflammation?

NSAIDs affect all three. What explains the difference?

This thread, a cross-over with the CORE IM, will try to answer these questions.

twitter.com/COREIMpodcast/…

For anyone who attended my TWDFNR session, please send along questions and comments. I’ll reply here!

Wow! We learned so much! How about you? 🤯
Diuresis speed: bit.ly/3VZl3GD
Pip/tazo vs Cefepime: bit.ly/4aBorvO
Periop ACE/ARB: bit.ly/3xuiWjO
Asymptomatic HTN: bit.ly/3Q1YL3o
#SHMConverge24 #MoreThanAJournal
VA by Catie Glatz, MD

5/
The differences in anatomy result from distinct embryologic origins. The smooth muscle cells of the TA derive from neural crest cells whereas the AA derives from mesodermal cells.

Amazingly, the thoracic and abdominal aorta are distinct organs!

linkinghub.elsevier.com/retrieve/pii/S…

We wrote a thing!
Arbitrary discharge time doesn't really help hospital flow. As with all things in medicine, it's just more complicated than that.

Things We Do for No Reason™: Discharge before noon - Dunn - Journal of Hospital Medicine - …mpublications.onlinelibrary.wiley.com/doi/10.1002/jh…

1/
Ever wonder: Why are abdominal aortic aneurysms (AAAs) more common than thoracic aortic aneurysms (TAAs)?

I have!

Follow this thread to see how the answer to this question makes use of long-forgotten medical classes. And there’ll be an appearance by The Great Mimicker.