Our study 'Spatially targeted chemokine exocytosis guides transmigration at lymphatic endothelial multicellular junctions' is now out!

embopress.org/doi/full/10.10…

Big congratulations also to Diego, one of the very first MetaStem PhD's in 2018, for the Academy Research Fellow funding. It has been great to watch your transition to group leader this last year 🎉

Congrats Väinö! This is a huge study with lots of implications, also for the imaging of focal CHI and islet tumors!

Check out this beautiful study by talented Väinö Lithovius and colleagues: Follow up of implanted SC-islets with PET. Important tools and findings for the development of diabetes cell therapies. Congrats to all authors!

9) Human specific C-peptide measurements under fasted, glucose-stimulated and hypoglycaemic conditions are poor predictors of engrafted SC-islet beta cell mass.
(Very few papers report quantifications of engrafted volume, and rely on implanted doses, not the same thing)

5) In longitudinal 18F-exendin scanning, we show that using the current protocols, unwanted growth occurs later, visible only at 5 months. Pure grafts remain stable

4) 1We could accurately and noninvasively quantify the actual engrafted size of the SC-islet grafts using 18F- exendin or 18F-DOPA PET. Not possible with other available methods

3) With 18F-FDOPA and especially 18F-exendin PET, we can detect even very small (1 mm3) grafts

2) We show that upon engraftment, the SC-islets develop either very small and pure or large and impure grafts with fluid-filled cysts

1) Glucose-responsive SC-islets can be produced with current protocols (DOI:10.1016/j.stemcr.2018.12.012 ; DOI:10.1038/s41587-022-01219-z) and are used in the clinic for T1D cell replacement therapy (NCT04786262). However, monitoring them after engraftment remains a challenge

Out today!
Stem cell -islets are used clinically for T1D cell replacement therapy, but non-invasive monitoring methods are lacking. We applied PET to quantify SC-islet graft size and assess their β cell and cyst % in mice. Diabetologia Turku PET Centre
rdcu.be/dKLrC

Warmest congrats for new Academy researchers and Clinical academy researchers in STEMM Research Program: Diego Balboa Kirmo Rubén Torregrosa!

💎🎉🥳🎉Warmest congratulations to new Academy Research Fellows Diego Balboa STEMM Research Program Heidi Haikala Heidi Haikala Andrew Erickson, Rubén Torregrosa-Muñumer and Sara Gandolfi Medicine and Health, University of Helsinki Research Programs Unit! University of Helsinki

💥Postdoc and PhD positions open for highly motivated enthusiast of hematopoietic stem cells at Helsinki University Institute of Biotechnology (BI) HiLIFE_Helsinki in the happiest country of the world: Finland 🇫🇮
Link here: lengefeldlab.com
Please RT 🙏 We are excited for your application!😃

1/7 I’m excited to introduce my second paper in my PhD! Click link here:
biorxiv.org/content/10.110…

Check out the last instalment of Jamie Chu 's odyssey of insulin gene activity state analyses... now with proteomics and a targeted mini-screen. Jamie will be presenting a different story at the EISG 2024 meeting next week. He is looking for a great post-doc lab :-)

Excited to share our recent preprint where we describe a novel somatostatin signaling pathway in beta cells involving cilia Ca2+ and cAMP changes and crosstalk with the hedgehog pathway.
biorxiv.org/cgi/content/sh…

Please check out out our paper with JacksonLab and Brendan Battersby👇
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation cell.com/iscience/fullt…
Geoffray Monteuuis Krysia Broda 🔬 Elizabeth Pyman Diego Balboa 1/7

The Novo Nordisk Foundation Research Leader Programme aims to support researchers at various stages of their careers, providing them with the necessary resources to conduct groundbreaking research. This year, we are supporting 41 exceptional research projects across a broad