There is great motivation among researchers to act on the pathogenesis of #type1diabetes . What do we know about how #T1D develops? And what starting points does this process offer? Article Artsenkrant Professor Cm [Dutch/French] innodia.eu/downloads/pdf/…

I've spent a long time resisting the idea of a central role for TEs to the evolution of complexity. Sure, they've contributed to some important innovations, like adaptive immunity, placental development, light responsiveness in plants and a whole bunch of transcription factors.

📢📢Looking for a #PhD student for the lab Babraham Institute 🐭⌛️👤⏳

Researchers: Please share the info with grad students that you think may be interested

Grad students: Check if this project interests you & get in touch!

findaphd.com/phds/project/d…

Very happy to present our study on the off-target activity of the genome editor Cas9. It has been in the works for a long time. Huge thanks and congratulations to Martin Pacesa and all our collaborators Caribou Biosciences Giulia Palermo and Allain lab.

authors.elsevier.com/sd/article/S00…

I’m so happy to announce that the results of our study on the mechanistic basis of Cas9 off-target activity have been published in Cell!

cell.com/cell/fulltext/…

New paper: INSERT‑seq enables high‑resolution mapping of genomically integrated DNA using Nanopore sequencing ow.ly/8jfh50Ll29U

Work lead by our CSO Marc Güell at UPF Medicine and Life Sciences and collaborative effort by talented scientists Dimitrije, Júlia Mir Pedrol and our CEO AvenciaSanchezMejias.

Our former preprint “Zmiz1 is required for mature β-cell function….” is now published Molecular Metabolism!
Huge thanks to all contributing authors! Shout-out to the MacDonald Lab Patrick MacDonald and our collaborators Nicole Krentz Anna Gloyn for such a great team effort!

sciencedirect.com/science/articl…

Great to see this out! Vikash Chandra and Hazem Ibrahim were able to pinpoint a specific role for TYK2 in controlling the endocrine progenitor cell cycle. Collaborative effort within INNODIA supports the use of TYK2 inhibitors for T1D prevention. rdcu.be/cYkB2

'TYK2 inhibition in adult β-cells is proposed as a potent therapeutic target to halt #T1D progression'

Checkout our new paper deciphering the role of the T1D gene TYK2 on beta-cell development and interferon responses.
Thankful for the great collaborative effort!
Vikash Chandra Timo Otonkoski MetaStem University of Helsinki STEMM Research Program INNODIA
⬇️
nature.com/articles/s4146…

New from Patrick MacDonald Anna Gloyn Mouse and human data reveal the importance of the zinc finger transcriptional regulator Zmiz1 for β-cell function #islets #insulin #diabetes Molecular Metabolism #GWAS #Genetics sciencedirect.com/science/articl…

nature.com/articles/s4146…

Oocytes rely on maternal mRNAs for development into healthy eggs. But where and how are these mRNAs stored?

Our latest work in Science Magazine shows that mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment (MARDO). bit.ly/3MNQSf1 (1/9)

Why can't I develop into a Darwinian demon like I desperately want to? Because evolutionary trade-offs prevent me from optimizing all traits simultaneously. Our story looking at trade-offs of immunity is now out in Science Magazine.
science.org/doi/10.1126/sc…

A mini-review from our lab on 'In vitro models of pre- and post-gastrulation embryonic development' sciencedirect.com/science/articl…

New paper from Manzanares lab lab Centro Biología Molecular Severo Ochoa (CSIC-UAM) out today in Cell Reports! Together with Ana Losada’s lab Losada Lab CNIO Stop Cancer and led by María José Andreu, we studied CTCF in early mouse development (cell.com/cell-reports/f…) 1/n

New preprint from the lab!
Using the STEM CELL ZOO, we recapitulated the SEGMENTATION CLOCKS of SIX mammals: mouse, marmoset, rabbit, human, cow & rhinoceros!
With the power of 6 species, we found several scaling laws of the segmentation clock periods.
doi.org/10.1101/2022.1…
1/

Have you ever wondered why stem cells of the gut have such a peculiar shape? So did we. Happy to share our latest results Science Advances including last bits of my thesis work Katajisto Lab 🥳