Just a day or so late 😂

Check out that KM curve for SANO-1 trial of EsoCa (SCC or Adeno) with cCR after CRT randomized to surgery or active surveillance

🔥Non-inf OS and ⬆️QoL with AS

SANO-2 and ESOSTRATE will clarify further
rb.gy/t8j2ep
rb.gy/y3bjbw

Finally! Look forward to this presentation at #ASCO24

Wow. FTC Announces Rule Banning #Noncompetes . A few highlights of the Final Rule:
◽️Calls out protections for physicians by name📷
◽️Rule takes effect for all workers starting 120 days from when this rule is published in the Federal Register
◽️After day 120, no new #noncompetes

Just in BMC 👉Full protocol of our recently initiated, National Cancer Institute RO1 funded, randomized trial of creatine supplementation + Resistance training in advanced #ProstateCancer undergoing ADT Adriana M Coletta, PhD, MS, RD Neli Ulrich, PhD OncoAlert PCF Science Huntsman Cancer Institute UroToday.com

⁦Ethan Ludmir MD⁩ giving an excellent lecture on #Radiotherapy in Intrahepatic Cholangiocarcinoma ⁦Cholangiocarcinoma Foundation⁩ 2024 meeting ⁦MD Anderson Cancer Center⁩ ⁦Albert Koong, MD PhD⁩ ⁦Eugene J. Koay, MD, PhD⁩

Optimal CTV design is uncertain but likely that anatomic delineation is better than isotropic

NRG Oncology contouring atlas being developed based on expert opinion led by Dr. Nina Niu Sanford so stay tuned!

I now use hybrid of JHU triangle volume + 0848 using vascular structure expansions

Outstanding talk covering locally advanced and oligometastatic lung cancer from incoming School of Medicine Trinity St James's Cancer Institute Marie Curie Prof. Gerry Hanna #ailcc24 #lcsm

Key Opinion Leaders react to Bristol Myers Squibb announcement of CHECKMATE 9DW (topline results for the treatment of Advanced Hepatocellular Carcinoma) #mhcc #HCC Top Tweets from Mark Yarchoan Dr Amol Akhade Tanios Bekaii-Saab, MD Dr. Cathy Eng Arndt Vogel
👉beta.kolpulse.com/public/1409290…

#Radioembolization with PD vs SD more than doubles survival for advanced #HCC in long-term analysis of #Dosisphere01 (HR 0.51).

>50% of patients downstaged to resection alive at 5 years.

Y90+IO+Surgery next..?

#Multidisciplinary is the way 🧩

jnm.snmjournals.org/content/early/…

Just waited on hold for 1 hour with Aetna Evicore EviCore By Evernorth Aetna to get approval for a staging CT CAP for Anal Cancer which they denied as well as denied a PET/CT which is clearly indicated in the NCCN guidelines
Sad that Aetna and Evicore deny cancer patients necessary

An unexpected (to me) outcome from molecular analysis of GOG 258. p53 wild type might benefit from EBRT in addition to chemo! This is the opposite of early stage disease, where p53abn seems to benefit from EBRT rather than VBT. PMID: 37487144. #radonc

Paraganglioma week 1/6
Case based reviews
In my practice:
· rarely/never biopsy (bleed risk)
· SRS (15 Gy) for smaller lesions, large lesions 45-50.4 Gy
· Surgery consider if already CN deficits/low risk
sciencedirect.com/science/articl…

Pleased to have contributed to design/conduct of study of ctDNA to screen for CRC; shows 83% sensitivity; 90% specificity. ⁦ASCO⁩ ⁦⁦ASCOPost⁩ AACR⁩ ⁦Fight Colorectal Cancer⁩ ⁦Mayo Clinic⁩ Mayo ClinicGIHep⁩ ⁦⁦American Gastroenterological Association (AGA)⁩ nejm.org/doi/full/10.10…

45 is the new 50 when it comes to colorectal cancer screening!

⁦Intermountain Health⁩ ⁦Alta View Hospital⁩ #crcsm

Partially Ablative Body Radiotherapy (PABR): A novel approach for pall... sciencedirect.com/science/articl…

Kudos to the PABR team and Peter Mac Radiation Oncology fellow Kelvin Ken Yu to get this to Radiotherapy & Oncology .Effective palliation for these unfortunate patients. Now onto the prospective trial!

This study assesses an important rectal cancer question, particularly in era of organ preservation:

After chemoRT, are visible (but smaller) pelvic LNs on MRI pathologic? I.e. if complete intraluminal response, can patient go onto surveillance vs. needing TME for nodes?

Series

Remarkable study!

Criteria for asymptomatic high-risk polymetastatic bone mets include:

📌 >2 cm (“bulky”).
📌 Junctional spine/posterior spinal elements involvement.
📌 Hip, shoulder, or SI joint disease.
📌 Long bone mets affecting 1/3-2/3 cortical thickness.

#radonc #AMSM

· 2nd case resected large brain metpost-op SRS (27/3)
· Risk LMD pre-op SRS ~6% vs. post-op ~20%
· Pertinent ongoing trial NRG BN012 pre vs. post-op SRS Stuart Burri, M.D.

Short course RT vs long course chemoRT in elderly pts (75+) w rectal ca (PRODIGE 42).

Short course RT achieved better QOL & preservation of autonomy!

Underscores that most patients enrolling on trials are healthier & younger, so results cannot be extrapolated across the board.

🎙 HARD RT shows promising locoregional control with acceptable tox for unresected STS❗️❗️OncoAlert a
📌Retro study- HARD RT applied to unresected STS (2019-2022), 27 👥
Dose Variation:HR: 3.0 Gy, IR: 2.5 Gy, LR: 2.0-2.3 Gy per fx
📊RESULTs
-FU Median 33.4 m
-100% LC at 3 y