Multi-omic single-cell velocity models epigenome–transcriptome interactions and improves cell fate prediction

nature.com/articles/s4158…

Assistant professor vs Editor

We are hiring at all levels! Postdocs & PhD students (computational & wetlab) for exciting single cell and spatial genomic projects to unravel mechanisms of fibrosis and identify novel drug targets and biomarkers for translation. Join our terrific team Please RT 👇👇

Excited to reconstruct and analyze *Dynamic* Gene Regulatory Networks along single cell RNA+ATAC trajectories with Lingfei Wang and Nikolaos Trasanidis ! Check out our new method Dictys ( <δίκτυον ) biorxiv.org/content/10.110…

Biology must generate ideas as well as data nature.com/articles/d4158…

#AcademicTwitter #AcademicChatter

News &Views by Wehrens, Timmer & van Rooij Hubrecht Institute on the recent #spatial #singlecells multi- #omics atlas of human #myocardialinfarction published @nature. nature.com/articles/s4416…| Rafael Kramann, MD PhD Julio Saez-Rodriguez
Christoph Kuppe, MD FASN Zhijian Li Ricardo O. Ramirez Flores

👉rdcu.be/cUMOv

Excited to share our findings training GPN, a DNA language model for Arabidopsis thaliana, with @sanjitsbatra and Yun S. Song:
DNA language models are powerful predictors of non-coding variant effects, without the need for any labeled data.
doi.org/10.1101/2022.0…
1/n

Excited to share with everyone an accessible, intuitive tutorial on diffusion models! If you're curious about the math behind diffusion models and how their different interpretations can be unified, please check it out!

Stay tuned for a blog post soon!

arxiv.org/abs/2208.11970

I described what DNA looks like, and DALL E gives me this picture.

Playing around with DALL.E and here is what I got.

I first tried 'the three body problem' to see if DALL.E read this famous sci-fi novel, one of my favorites.

A good starting point for perturbation modeling development

We are thrilled to see our new paper out nature! (nature.com/articles/s4158…). We generated a spatially resolved single-cell multi-omics atlas of human myocardial infarction from 23 patients, spanning multiple tissue regions, including over 200k nuclei and 28 spatial samples. 1/n

Many people were curious to know how I created this illustration (cover proposal for nature) - so here is an *honest* stepwise thread on how my #sciart process typically looks like! ✨

A 🧵
#scicomm #sciviz #sciart portfolioweek

In this new paper, I described comprehensively the current features of ComplexHeatmap. Thank the executive editor Yong-Xin Liu from iMeta journal for the paper invitation!

doi.org/10.1002/imt2.43

By far, the most accurate representation of machine learning pipelines in the real world 🍿 😀

I am pleased to share with you my review about cell types, published in Cell yesterday. 1/

What is a cell type and how to define it? cell.com/cell/fulltext/…

‼️ ONLINE NOW Nature Genetics
📰 A sequence-based global map of regulatory activity for deciphering human genetics
🧑🏿‍🤝‍🧑🏻 Jian Zhou Olga Troyanskaya and team
👇🏻
go.nature.com/3ACPk3m